Jeffrey Apfelbaum, M.D.
Professor
Professor
Secondary Title:
Chairman
Chairman
Training:
B.A. - 1974
Swarthmore College, Swarthmore
Pennsylvania - Molecular Genetics Biochemistry
M.D. - 1978
Northwestern University School of Medicine
Chicago, Illinois - Medicine
B.A. - 1974
Swarthmore College, Swarthmore
Pennsylvania - Molecular Genetics Biochemistry
M.D. - 1978
Northwestern University School of Medicine
Chicago, Illinois - Medicine
Internship - 1978-79
Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania - Medicine
Residency - 1979-81
University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania - Anesthesia
Fellowship - 1983
University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania - Anesthesia
Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania - Medicine
Residency - 1979-81
University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania - Anesthesia
Fellowship - 1983
University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania - Anesthesia
Academic Interests:
Recovery from anesthetics; recovery from sedation/hypnosis; short acting, fast emergence anesthetics; multi-model postoperative pain management in analgesia patients.
Recovery from anesthetics; recovery from sedation/hypnosis; short acting, fast emergence anesthetics; multi-model postoperative pain management in analgesia patients.
Clinical Interests:
Ambulatory Anesthesia.
Ambulatory Anesthesia.
Representative Publications:
1. Gross JB, Caldwell CB, Shaw LM, Apfelbaum JL: Effect of lidocaine infusion on the ventilatory response to hypoxia. Anesthesiology 61:662-666, 1984
2. Coodley EL, Miller H, Frocco G, Goldzer R, LaBove N, LeSal J, Neimark S, Victor M, Whittington R, Apfelbaum JL: Therapeutic conference: Problem: Fever, nausea, back pain. Emerg Med 16:57-64, 1984
3. Spaulding BC, Choi SD, Gross JB, Apfelbaum JL, Broderson H: The effect of physostigmine on diazepam-induced ventilatory depression: A double-blind study. Anesthesiology 61:551-554, 1984
4. Choi SD, Spaulding BC, Gross JB, Apfelbaum JL: Comparison of the ventilatory effects of etomidate and methohexital. Anesthesiology 62:442-447, 1985
5. Apfelbaum JL, Shaw LM, Gross JB, Caldwell CB, Spaulding BC: Modifications of lidocaine protein binding with CO2. Can Anaesth Soc J 32:468-471, 1985
6. Moss J, Roizen MF, Norbody EJ, Thisted R, Apfelbaum JL, Schreider BD, McDermott DJ: Decreased incidence and mortality of anaphylaxis to chymopapain. Anesth Analg 64:1197-1201, 1985
7. Leighton BL, Cheek TG, Gross JB, Apfelbaum JL, Shantz BB, Gutsche BB, Rosenberg H: Succinylcholine pharmacodynamics in peripartum patients. Anesthesiology 64:202-206, 1986
8. Conahan TJ, Williams GD, Apfelbaum JL, Lecky JH: Airway heating reduces recovery time (cost) in outpatients. Anesthesiology 61:128-130, 1987
9. Apfelbaum JL, Schreider BD: Organizational aspects of day-case surgery. Curr Opin Anaesth 1:48-53, 1988
10. Marais ML, Maher MW, Wetchler BV, Korttila K, Apfelbaum JL: Reduced demands on recovery room resources with propofol (Diprivan) compared to thiopental-isoflurane. Anesthesiol Rev 16:29-40, 1989
11. Zahl K, Apfelbaum JL: Muscle pain occurs after outpatient laparoscopy despite the substitution of vecuronium for succinylcholine. Anesthesiology 70:408-411, 1989
12. Korttila K, Östman PL, Faure E, Apfelbaum JL, Ekdawi M, Roizen MF: Randomized comparison of outcome after propofol-nitrous oxide or enflurane-nitrous oxide anaesthesia in operations of long duration. Can J Anaesth 36:651-657, 1989
13. Apfelbaum JL: Ambulatory surgery: A historical perspective. Anesthesiol Rev 17 (Suppl 2):2-3, 1990
14. Apfelbaum JL: Preoperation evaluation, laboratory screening, and selection of adult surgical outpatients in the 1990s. Anesthesiol Rev 17 (Suppl 2):4-12, 1990
15. Apfelbaum JL: Discussion highlights (part 1). Anesthesiol Rev 17 (Suppl 2):28-31, 1990
16. Apfelbaum JL: Discussion highlights (part 2). Anesthesiol Rev 17 (Supl 2) 64-66, 1990
17. Korttila K, Östman P, Faure E, Apfelbaum JL, Prunskis J, Ekdawi M, Roizen MF: Randomized comparison of recovery after propofol-nitrous oxide versus thiopentone-isoflurane-nitrous oxide anaesthesia in patients undergoing ambulatory surgery. Acta Anaesthesiol Scand 34:400-403, 1990
18. Apfelbaum JL: Complications and quality assurance. Acta Anaesth Scand 35(Suppl): I-37, 1991
19. Apfelbaum JL: Organization and case selection. Acta Anaesth Scand 35(Suppl):I-33, 1991
20. Lichtor JL, Zacny J, Korttila K, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C: Alcohol after midazolam sedation: does it really matter? Anesth Analg 72:661-666, 1991
21. Korttila K, Nuotto EJ, Lichtor JL, Östman PL, Apfelbaum J, Rupani G: Clinical recovery and psychomotor function after brief anesthesia with propofol or thiopental. Anesthesiology 76:676-681, 1992
22. Zacny JP, Lichtor JL, Coalson DW, Finn RS, Uitvlugt AM, Glosten B, Flemming DC, Apfelbaum JL: Subjective and psychomotor effects of subanesthetic doses of propofol in healthy volunteers. Anesthesiology 76:696-702, 1992
23. Lichtor JL, Zacny J, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C, Korttila K: Alcohol after sedation with I.V. midazolam-fentanyl: effects on psychomotor functioning. Br J Anaesth 67:579-584, 1992
24. Apfelbaum JL: Mivacurium infusion. J Drug Dev S2:21-24, 1992
25. Roizen MF, Coalson D, Hayward RSA, Schmittner J, Thisted RA, Apfelbaum JL, Stocking CB, Cassel CK, Pompei P, Ford DE, Steinberg EP: Can patients use an automated questionnaire to define their current health status? Med Care 30:MS74-MS84, 1992
26. Apfelbaum JL, Glosten B: Preoperative laboratory screening tests. Curr Surg 49:22-27, 1992
27. Apfelbaum JL, Kallar SK, Wetchler B: Muscle relaxants for outpatient surgery: old and new. J Clin Anesth 4:2S-8S, 1992
28. Zacny JP, Lichtor JL, Zaragoza JG, Coalson DW, Uitvlugt AM, Flemming DC, Binstock WB, Cutter T, Apfelbaum JL: Assessing the abuse potential of propofol bolus injections in healthy volunteers. Drug Alcohol Depend 32:45-57, 1993
29. Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF: The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: Characteristics associated with prolonged time to awakening. Anesth Analg 77:S10-S14, 1993
30. Grasela TH, Watkins WD, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL: The role of pharmacoepidemiology research in postmarketing surveillance and anesthesia practice/critical care medicine. Anesth Analg 77:S44-S50, 1993
31. Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH: Hemodynamic effects of propofol: Data from over 25,000 patients. Anesth Analg 77:S21-S29, 1993
32. McLeskey CH, Walawander CA, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr: Adverse events in a multicenter phase IV study of propofol: Evaluation by anesthesiologists and postanesthesia care unit nurses. Anesth Analg 77:S3-S9, 1993
33. Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH: Phase IV study of propofol: Validation of the data set. Anesth Analg 77:S34-S43, 1993
34. Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML: How do anesthesiologists select patients when introducing a new drug into practice? Anesth Analg 77:S30-S33, 1993
35. Lichtor JL, Zacny JP, Coalson DW, Flemming DC, Uitvlugt A, Apfelbaum JL, Lane BS, Thisted RA: The interaction between alcohol and the residual effects of thiopental anesthesia. Anesthesiology 79:28-35, 1993
36. Zacny JP, Lichtor, JL, Zaragoza JG, Apfelbaum JL: The effects of a 5-HT3 antagonist, ondansetron, on cigarette smoking, smoke exposure and mood in humans. Pharmacol Biochem Behav 44:387-391, 1993
37. Scuderi P, Wetchler B, Sung YF, Mingus M, DePen S, Clayton L, Leslie J, Talke P, Apfelbaum JL, Sharifi-Azad S, Williams MF: Treatment of postoperative nausea and vomiting after outpatient surgery with the 5HT3 antagonist ondansetron. Anesthesiology 78:15-20, 1993
38. White PF, Stanley TH, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Thisted RA, Walawander CA: Effects on recovery when isoflurane is used to supplement propofol-nitrous oxide anesthesia. Anesth Analg 77:S15-S20, 1993
39. Zacny JP, Lichtor JL, Thompson W, Apfelbaum JL: Propofol at a subanesthetic dose may have abuse potential in healthy volunteers. Anesth Analg 77:544-552, 1993
40. Zacny JP, Lichtor JL, Coalson DW, Flemming D, Apfelbaum JL, Foster V: Time course of effects of brief inhalations of nitrous oxide in normal volunteers. Addiction 89:831-839, 1994
41. Thapar P, Korttila KT, Apfelbaum JL: Assessing recovery after day-case surgery. Curr Anaesth Crit Care 5:155-159, 1994
42. Zacny JP, Coalson D, Young C, Klafta J, Rupani G, Thapar P, Choi M, Apfelbaum JL: A dose-response study of the effects of intravenous midazolam on cold pressor-induced pain. Anesth Analg 80:521-525, 1995
43. Thapar P, Zacny JP, Thompson W, Apfelbaum JL: Using alcohol as a metric to compare recovery profiles of often-used sedative agents in ambulatory surgery. Anesthesiology 82:53-59, 1995
44. Pirec V, Coalson DW, Lichtor JL, Klafta J, Young C, Rupani G, Apfelbaum JL, Zacny JP: Cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers. Exp Clin Psychopharmacol 3:148-155, 1995
45. Pirec V, Patterson TH, Thapar P Apfelbaum JL, Zacny JP: Effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans. Pharmacol Biochem Behav 51:323-329, 1995
46. Zacny JP, Yajnik S, Coalson D, Lichtor JL, Thapar P, Apfelbaum JL, Rupani G, Young C, Klafta J: Flumazenil may attenuate some subjective effects of nitrous oxide in humans: a preliminary report. Pharmacol Biochem Behav 51:815-819, 1995
47. Thapar P, Zacny JP, Choi M, Apfelbaum JL: Objective and subjective impairment from often-used sedative combinations in ambulatory surgery, using alcohol as a benchmark. Anesth Analg 80:1092-1098, 1995
48. Young CJ, Apfelbaum JL: Pharmacology of outpatient anesthesia in the year 2000. Acta Anaesthesiol Scand 39 (Suppl 105):75-83, 1995
49. Apfelbaum JL: Mivacurium chloride administration by infusion. Acta Anaesthesiol Scand Suppl 106:55-57, 1995
50. Young CJ, Apfelbaum JL: Inhalational anesthetics: desflurane and sevoflurane. J Clin Anesth 7:564-577,
51. Zacny JP, Cho AM, Coalson DW, Rupani G, Young CJ, Klafta JM, Klock PA, Apfelbaum JL: Differential acute tolerance development to effects of nitrous oxide in humans. Neurosci Lett 209:73-76, 1996
52. Zacny JP, Lichtor JL, Coalson DW, Alessi R, Goldsher G, Young CJ, Apfelbaum JL, Conley KM: Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers: a dose-response analysis. Behav Pharm 7:194-199, 1996
53. Young CJ, Apfelbaum JL. Adult clinical experience with sevoflurane and pharmaco-economic aspects. Acta Anaesthesiol Belg 47:29-42, 1996
54. Apfelbaum JL, Lichtor JL, Lane BS, Coalson DW, Korttila KT: Awakening, clinical recovery, and psychomotor effects after desflurane and propofol anesthesia. Anesth Analg 83:721-725, 1996
55. Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JL: Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav 54:501-508, 1996
56. Zacny JP, Coalson DW, Young CJ, Klafta JM, Lichtor JL, Rupani G, Thapar P, Apfelbaum JL: Propofol at conscious sedation doses produces mild analgesia to cold pressor-induced pain in healthy volunteers. J Clin Anesth 8:469-474, 1996
57. Zacny JP, McKay MA, Toledano AY, Marks S, Young CJ, Klock PA, Apfelbaum JL: The effects of a cold-water immersion stressor on the reinforcing and subjective effects of fentanyl in healthy volunteers. Drug Alcohol Depend 42:133-142, 1996
58. Zacny JP, Lichtor JL, Klafta JM, Alessi R, Apfelbaum JL: The effects of transnasal butorphanol on mood and psychomotor functioning in healthy volunteers. Anesth Analg 82:931-935, 1996
59. Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL: The acute residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and pyschomotor performance in healthy volunteers. Anesth Analg 82:153-157, 1996
60. Zacny JP, Klafta JM, Coalson DW, Marks S, Young CJ, Kock PA, Toledano AY, Jordan N, Apfelbaum JL: The reinforcing effects of brief exposures to nitrous oxide in healthy volunteers. Drug Alcohol Depend 42:197-200, 1996
61. Zacny JP, Coalson DW, Klafta JM, Klock PA, Alessi R, Rupani G, Young CJ, Patil PG, Apfelbaum JL: Midazolam does not influence intravenous fentanyl-induced analgesia in healthy volunteers. Pharmacol Biochem Behav 55:275-280, 1996
62. Zacny JP, Lichtor JL, Coalson DW, Alessi R, Goldsher G, Young CJ, Apfelbaum JL, Conley KM: Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers: a dose-response analysis. Behav Pharmacol 7:194-199, 1996
63. Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP: The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend 45:63-70, 1997
64. Galinkin JL, Janiszewski D, Young CJ, Klafta JM, Klock PA, Coalson DW, Apfelbaum JL, Zacny JP: Subjective, psychomotor, cognitive, and analgesic effects of subanesthetic concentrations of sevoflurane and nitrous oxide. Anesthesiology 87:1082-1088, 1997
65. Young CJ, Coalson D, Klock PA, Klafta JM, Goldsher G, Apfelbaum JL, Zacny JP: Analgesic and psychomotor effects of thiopental at subanesthetic concentrations in human volunteers. Acta Anaesthesiol Scand 41:903-910, 1997
66. Conley KM, Toledano AY, Apfelbaum JL, Zacny JP: Modulating effects of a cold water stimulus on opioid effects in volunteers. Psychopharmacology 131:313-320, 1997
67. Apfelbaum JL, O'Connor MF: Update on transfusion therapy. Semin Cardiothorac Vasc Anesth 4:236-243, 2000
68. O'Connor MF, Daves SM, Tung A, Cook RI, Thisted RA, Apfelbaum JL: BIS monitoring to prevent awareness during general anesthesia. Anesthesiology 94:520-522, 2001
69. Silverstein JH, Apfelbaum JL, Barlow JC, Chung FF, Connis RT, Fillmore RB, Hunt SE, Joas TA, Nickinovich DG, Schreiner MS: American Society of Anesthesiologists Task Force on Postanesthesia Care: Practice guidelines for postanesthetic care: a report by the American Society of Anesthesiologists Task Force on Postanesthetic Care. Anesthesiology 96:742-752, 2002
70. Apfelbaum JL, Walawander CA, Grasela TH, Wise P, McLeskey C, Roizen MF, Wetchler BV, Corttila K: Eliminating Intensive Postoperative Care in Same Day Surgery Patients Using Short Acting Anesthetics. Anesthesiology 97:66-74, 2002
71. Abouleish A.E., Prough DS, Barker SJ, Whitten CW, Uchida T, Apfelbaum JL. Organizational Factors Affect Comparisons of Clinical Productivity of Academic Anesthesiology Departments. Anesth Analg 96: 802-812; 2003
72. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative Pain Experience: Results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 2003; 97:534-40.
74. Apfelbaum JL, Gan TJ, Zhao S, Hann DB, Chen C. Reliability and Validity of the Perioperative Opioid-Related Symptom Distress Scale. Anesth Analg 2004; 99:699-709
75. Abouleish AE, Apfelbaum JL, Prough DS, Willims JP, Roskoph JA, Johnston WE, Whitten CW. Prevalence and characteristics of incentive plans for clinical productivity among academic anesthesiology programs. Anesth Analg 2005; 100:493-501.
76. Abouleish AE. Apfelbaum JL. Prough DS. Williams JP. Roskoph JA. Johnston WE. Whitten CW. The prevalence and characteristics of incentive plans for clinical productivity among academic anesthesiology programs.[see comment]. [Journal Article] Anesth Analg 2005; 100(2):493-501.
76. Apfelbaum JL, Arens JF, Cole DJ, Connis RT, Domino KB, Drummond JC, Kalkman CJ, Miller RD, Nickinovich DG, Todd MM. Practice Advisory for Intraoperative Awareness and Brain Function Monitoring. Anesthesiology; 104(4):847-864.
1. Gross JB, Caldwell CB, Shaw LM, Apfelbaum JL: Effect of lidocaine infusion on the ventilatory response to hypoxia. Anesthesiology 61:662-666, 1984
2. Coodley EL, Miller H, Frocco G, Goldzer R, LaBove N, LeSal J, Neimark S, Victor M, Whittington R, Apfelbaum JL: Therapeutic conference: Problem: Fever, nausea, back pain. Emerg Med 16:57-64, 1984
3. Spaulding BC, Choi SD, Gross JB, Apfelbaum JL, Broderson H: The effect of physostigmine on diazepam-induced ventilatory depression: A double-blind study. Anesthesiology 61:551-554, 1984
4. Choi SD, Spaulding BC, Gross JB, Apfelbaum JL: Comparison of the ventilatory effects of etomidate and methohexital. Anesthesiology 62:442-447, 1985
5. Apfelbaum JL, Shaw LM, Gross JB, Caldwell CB, Spaulding BC: Modifications of lidocaine protein binding with CO2. Can Anaesth Soc J 32:468-471, 1985
6. Moss J, Roizen MF, Norbody EJ, Thisted R, Apfelbaum JL, Schreider BD, McDermott DJ: Decreased incidence and mortality of anaphylaxis to chymopapain. Anesth Analg 64:1197-1201, 1985
7. Leighton BL, Cheek TG, Gross JB, Apfelbaum JL, Shantz BB, Gutsche BB, Rosenberg H: Succinylcholine pharmacodynamics in peripartum patients. Anesthesiology 64:202-206, 1986
8. Conahan TJ, Williams GD, Apfelbaum JL, Lecky JH: Airway heating reduces recovery time (cost) in outpatients. Anesthesiology 61:128-130, 1987
9. Apfelbaum JL, Schreider BD: Organizational aspects of day-case surgery. Curr Opin Anaesth 1:48-53, 1988
10. Marais ML, Maher MW, Wetchler BV, Korttila K, Apfelbaum JL: Reduced demands on recovery room resources with propofol (Diprivan) compared to thiopental-isoflurane. Anesthesiol Rev 16:29-40, 1989
11. Zahl K, Apfelbaum JL: Muscle pain occurs after outpatient laparoscopy despite the substitution of vecuronium for succinylcholine. Anesthesiology 70:408-411, 1989
12. Korttila K, Östman PL, Faure E, Apfelbaum JL, Ekdawi M, Roizen MF: Randomized comparison of outcome after propofol-nitrous oxide or enflurane-nitrous oxide anaesthesia in operations of long duration. Can J Anaesth 36:651-657, 1989
13. Apfelbaum JL: Ambulatory surgery: A historical perspective. Anesthesiol Rev 17 (Suppl 2):2-3, 1990
14. Apfelbaum JL: Preoperation evaluation, laboratory screening, and selection of adult surgical outpatients in the 1990s. Anesthesiol Rev 17 (Suppl 2):4-12, 1990
15. Apfelbaum JL: Discussion highlights (part 1). Anesthesiol Rev 17 (Suppl 2):28-31, 1990
16. Apfelbaum JL: Discussion highlights (part 2). Anesthesiol Rev 17 (Supl 2) 64-66, 1990
17. Korttila K, Östman P, Faure E, Apfelbaum JL, Prunskis J, Ekdawi M, Roizen MF: Randomized comparison of recovery after propofol-nitrous oxide versus thiopentone-isoflurane-nitrous oxide anaesthesia in patients undergoing ambulatory surgery. Acta Anaesthesiol Scand 34:400-403, 1990
18. Apfelbaum JL: Complications and quality assurance. Acta Anaesth Scand 35(Suppl): I-37, 1991
19. Apfelbaum JL: Organization and case selection. Acta Anaesth Scand 35(Suppl):I-33, 1991
20. Lichtor JL, Zacny J, Korttila K, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C: Alcohol after midazolam sedation: does it really matter? Anesth Analg 72:661-666, 1991
21. Korttila K, Nuotto EJ, Lichtor JL, Östman PL, Apfelbaum J, Rupani G: Clinical recovery and psychomotor function after brief anesthesia with propofol or thiopental. Anesthesiology 76:676-681, 1992
22. Zacny JP, Lichtor JL, Coalson DW, Finn RS, Uitvlugt AM, Glosten B, Flemming DC, Apfelbaum JL: Subjective and psychomotor effects of subanesthetic doses of propofol in healthy volunteers. Anesthesiology 76:696-702, 1992
23. Lichtor JL, Zacny J, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C, Korttila K: Alcohol after sedation with I.V. midazolam-fentanyl: effects on psychomotor functioning. Br J Anaesth 67:579-584, 1992
24. Apfelbaum JL: Mivacurium infusion. J Drug Dev S2:21-24, 1992
25. Roizen MF, Coalson D, Hayward RSA, Schmittner J, Thisted RA, Apfelbaum JL, Stocking CB, Cassel CK, Pompei P, Ford DE, Steinberg EP: Can patients use an automated questionnaire to define their current health status? Med Care 30:MS74-MS84, 1992
26. Apfelbaum JL, Glosten B: Preoperative laboratory screening tests. Curr Surg 49:22-27, 1992
27. Apfelbaum JL, Kallar SK, Wetchler B: Muscle relaxants for outpatient surgery: old and new. J Clin Anesth 4:2S-8S, 1992
28. Zacny JP, Lichtor JL, Zaragoza JG, Coalson DW, Uitvlugt AM, Flemming DC, Binstock WB, Cutter T, Apfelbaum JL: Assessing the abuse potential of propofol bolus injections in healthy volunteers. Drug Alcohol Depend 32:45-57, 1993
29. Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF: The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: Characteristics associated with prolonged time to awakening. Anesth Analg 77:S10-S14, 1993
30. Grasela TH, Watkins WD, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL: The role of pharmacoepidemiology research in postmarketing surveillance and anesthesia practice/critical care medicine. Anesth Analg 77:S44-S50, 1993
31. Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH: Hemodynamic effects of propofol: Data from over 25,000 patients. Anesth Analg 77:S21-S29, 1993
32. McLeskey CH, Walawander CA, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr: Adverse events in a multicenter phase IV study of propofol: Evaluation by anesthesiologists and postanesthesia care unit nurses. Anesth Analg 77:S3-S9, 1993
33. Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH: Phase IV study of propofol: Validation of the data set. Anesth Analg 77:S34-S43, 1993
34. Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML: How do anesthesiologists select patients when introducing a new drug into practice? Anesth Analg 77:S30-S33, 1993
35. Lichtor JL, Zacny JP, Coalson DW, Flemming DC, Uitvlugt A, Apfelbaum JL, Lane BS, Thisted RA: The interaction between alcohol and the residual effects of thiopental anesthesia. Anesthesiology 79:28-35, 1993
36. Zacny JP, Lichtor, JL, Zaragoza JG, Apfelbaum JL: The effects of a 5-HT3 antagonist, ondansetron, on cigarette smoking, smoke exposure and mood in humans. Pharmacol Biochem Behav 44:387-391, 1993
37. Scuderi P, Wetchler B, Sung YF, Mingus M, DePen S, Clayton L, Leslie J, Talke P, Apfelbaum JL, Sharifi-Azad S, Williams MF: Treatment of postoperative nausea and vomiting after outpatient surgery with the 5HT3 antagonist ondansetron. Anesthesiology 78:15-20, 1993
38. White PF, Stanley TH, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Thisted RA, Walawander CA: Effects on recovery when isoflurane is used to supplement propofol-nitrous oxide anesthesia. Anesth Analg 77:S15-S20, 1993
39. Zacny JP, Lichtor JL, Thompson W, Apfelbaum JL: Propofol at a subanesthetic dose may have abuse potential in healthy volunteers. Anesth Analg 77:544-552, 1993
40. Zacny JP, Lichtor JL, Coalson DW, Flemming D, Apfelbaum JL, Foster V: Time course of effects of brief inhalations of nitrous oxide in normal volunteers. Addiction 89:831-839, 1994
41. Thapar P, Korttila KT, Apfelbaum JL: Assessing recovery after day-case surgery. Curr Anaesth Crit Care 5:155-159, 1994
42. Zacny JP, Coalson D, Young C, Klafta J, Rupani G, Thapar P, Choi M, Apfelbaum JL: A dose-response study of the effects of intravenous midazolam on cold pressor-induced pain. Anesth Analg 80:521-525, 1995
43. Thapar P, Zacny JP, Thompson W, Apfelbaum JL: Using alcohol as a metric to compare recovery profiles of often-used sedative agents in ambulatory surgery. Anesthesiology 82:53-59, 1995
44. Pirec V, Coalson DW, Lichtor JL, Klafta J, Young C, Rupani G, Apfelbaum JL, Zacny JP: Cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers. Exp Clin Psychopharmacol 3:148-155, 1995
45. Pirec V, Patterson TH, Thapar P Apfelbaum JL, Zacny JP: Effects of subanesthetic concentrations of nitrous oxide on cold-pressor pain in humans. Pharmacol Biochem Behav 51:323-329, 1995
46. Zacny JP, Yajnik S, Coalson D, Lichtor JL, Thapar P, Apfelbaum JL, Rupani G, Young C, Klafta J: Flumazenil may attenuate some subjective effects of nitrous oxide in humans: a preliminary report. Pharmacol Biochem Behav 51:815-819, 1995
47. Thapar P, Zacny JP, Choi M, Apfelbaum JL: Objective and subjective impairment from often-used sedative combinations in ambulatory surgery, using alcohol as a benchmark. Anesth Analg 80:1092-1098, 1995
48. Young CJ, Apfelbaum JL: Pharmacology of outpatient anesthesia in the year 2000. Acta Anaesthesiol Scand 39 (Suppl 105):75-83, 1995
49. Apfelbaum JL: Mivacurium chloride administration by infusion. Acta Anaesthesiol Scand Suppl 106:55-57, 1995
50. Young CJ, Apfelbaum JL: Inhalational anesthetics: desflurane and sevoflurane. J Clin Anesth 7:564-577,
51. Zacny JP, Cho AM, Coalson DW, Rupani G, Young CJ, Klafta JM, Klock PA, Apfelbaum JL: Differential acute tolerance development to effects of nitrous oxide in humans. Neurosci Lett 209:73-76, 1996
52. Zacny JP, Lichtor JL, Coalson DW, Alessi R, Goldsher G, Young CJ, Apfelbaum JL, Conley KM: Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers: a dose-response analysis. Behav Pharm 7:194-199, 1996
53. Young CJ, Apfelbaum JL. Adult clinical experience with sevoflurane and pharmaco-economic aspects. Acta Anaesthesiol Belg 47:29-42, 1996
54. Apfelbaum JL, Lichtor JL, Lane BS, Coalson DW, Korttila KT: Awakening, clinical recovery, and psychomotor effects after desflurane and propofol anesthesia. Anesth Analg 83:721-725, 1996
55. Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JL: Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav 54:501-508, 1996
56. Zacny JP, Coalson DW, Young CJ, Klafta JM, Lichtor JL, Rupani G, Thapar P, Apfelbaum JL: Propofol at conscious sedation doses produces mild analgesia to cold pressor-induced pain in healthy volunteers. J Clin Anesth 8:469-474, 1996
57. Zacny JP, McKay MA, Toledano AY, Marks S, Young CJ, Klock PA, Apfelbaum JL: The effects of a cold-water immersion stressor on the reinforcing and subjective effects of fentanyl in healthy volunteers. Drug Alcohol Depend 42:133-142, 1996
58. Zacny JP, Lichtor JL, Klafta JM, Alessi R, Apfelbaum JL: The effects of transnasal butorphanol on mood and psychomotor functioning in healthy volunteers. Anesth Analg 82:931-935, 1996
59. Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL: The acute residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and pyschomotor performance in healthy volunteers. Anesth Analg 82:153-157, 1996
60. Zacny JP, Klafta JM, Coalson DW, Marks S, Young CJ, Kock PA, Toledano AY, Jordan N, Apfelbaum JL: The reinforcing effects of brief exposures to nitrous oxide in healthy volunteers. Drug Alcohol Depend 42:197-200, 1996
61. Zacny JP, Coalson DW, Klafta JM, Klock PA, Alessi R, Rupani G, Young CJ, Patil PG, Apfelbaum JL: Midazolam does not influence intravenous fentanyl-induced analgesia in healthy volunteers. Pharmacol Biochem Behav 55:275-280, 1996
62. Zacny JP, Lichtor JL, Coalson DW, Alessi R, Goldsher G, Young CJ, Apfelbaum JL, Conley KM: Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers: a dose-response analysis. Behav Pharmacol 7:194-199, 1996
63. Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP: The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend 45:63-70, 1997
64. Galinkin JL, Janiszewski D, Young CJ, Klafta JM, Klock PA, Coalson DW, Apfelbaum JL, Zacny JP: Subjective, psychomotor, cognitive, and analgesic effects of subanesthetic concentrations of sevoflurane and nitrous oxide. Anesthesiology 87:1082-1088, 1997
65. Young CJ, Coalson D, Klock PA, Klafta JM, Goldsher G, Apfelbaum JL, Zacny JP: Analgesic and psychomotor effects of thiopental at subanesthetic concentrations in human volunteers. Acta Anaesthesiol Scand 41:903-910, 1997
66. Conley KM, Toledano AY, Apfelbaum JL, Zacny JP: Modulating effects of a cold water stimulus on opioid effects in volunteers. Psychopharmacology 131:313-320, 1997
67. Apfelbaum JL, O'Connor MF: Update on transfusion therapy. Semin Cardiothorac Vasc Anesth 4:236-243, 2000
68. O'Connor MF, Daves SM, Tung A, Cook RI, Thisted RA, Apfelbaum JL: BIS monitoring to prevent awareness during general anesthesia. Anesthesiology 94:520-522, 2001
69. Silverstein JH, Apfelbaum JL, Barlow JC, Chung FF, Connis RT, Fillmore RB, Hunt SE, Joas TA, Nickinovich DG, Schreiner MS: American Society of Anesthesiologists Task Force on Postanesthesia Care: Practice guidelines for postanesthetic care: a report by the American Society of Anesthesiologists Task Force on Postanesthetic Care. Anesthesiology 96:742-752, 2002
70. Apfelbaum JL, Walawander CA, Grasela TH, Wise P, McLeskey C, Roizen MF, Wetchler BV, Corttila K: Eliminating Intensive Postoperative Care in Same Day Surgery Patients Using Short Acting Anesthetics. Anesthesiology 97:66-74, 2002
71. Abouleish A.E., Prough DS, Barker SJ, Whitten CW, Uchida T, Apfelbaum JL. Organizational Factors Affect Comparisons of Clinical Productivity of Academic Anesthesiology Departments. Anesth Analg 96: 802-812; 2003
72. Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative Pain Experience: Results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 2003; 97:534-40.
74. Apfelbaum JL, Gan TJ, Zhao S, Hann DB, Chen C. Reliability and Validity of the Perioperative Opioid-Related Symptom Distress Scale. Anesth Analg 2004; 99:699-709
75. Abouleish AE, Apfelbaum JL, Prough DS, Willims JP, Roskoph JA, Johnston WE, Whitten CW. Prevalence and characteristics of incentive plans for clinical productivity among academic anesthesiology programs. Anesth Analg 2005; 100:493-501.
76. Abouleish AE. Apfelbaum JL. Prough DS. Williams JP. Roskoph JA. Johnston WE. Whitten CW. The prevalence and characteristics of incentive plans for clinical productivity among academic anesthesiology programs.[see comment]. [Journal Article] Anesth Analg 2005; 100(2):493-501.
76. Apfelbaum JL, Arens JF, Cole DJ, Connis RT, Domino KB, Drummond JC, Kalkman CJ, Miller RD, Nickinovich DG, Todd MM. Practice Advisory for Intraoperative Awareness and Brain Function Monitoring. Anesthesiology; 104(4):847-864.
