Professor & Chairman

Apfelbaum JL, Desjardins PJ, Brown MT, Verburg KM. Multiple-day Efficacy of Parecoxib Sodium Treatment in Postoperative Bunionectomy Pain. Clin J Pain 2011; 24:784–792

Abouleish AE. Apfelbaum JL. Prough DS. Williams JP. Roskoph JA. Johnston WE. Whitten CW. The prevalence and characteristics of incentive plans for clinical productivity among academic anesthesiology programs. [see comment]. [Journal Article] Anesth Analg 2005; 100(2):493-501.

Apfelbaum JL, Gan TJ, Zhao S, Hann DB, Chen C. Reliability and Validity of the Perioperative Opioid-Related Symptom Distress Scale. Anesth Analg 2004; 99:699-709

Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative Pain Experience: Results from a national survey suggest postoperative pain continues to be under managed. Anesth Analg 2003; 97:534-40.

Abouleish A.E., Prough DS, Barker SJ, Whitten CW, Uchida T, Apfelbaum JL. Organizational Factors Affect Comparisons of Clinical Productivity of Academic Anesthesiology Departments. Anesth Analg 96: 802-812; 2003

Apfelbaum JL, Walawander CA, Grasela TH, Wise P, McLeskey C, Roizen MF, Wetchler BV, Corttila K: Eliminating Intensive Postoperative Care in Same Day Surgery Patients Using Short Acting Anesthetics. Anesthesiology 97:66-74, 2002

Silverstein JH, Apfelbaum JL, Barlow JC, Chung FF, Connis RT, Fillmore RB, Hunt SE, Joas TA, Nickinovich DG, Schreiner MS: American Society of Anesthesiologists Task Force on Postanesthesia Care: Practice guidelines for post anesthetic care: a report by the American Society of Anesthesiologists Task Force on Postanesthetic Care. Anesthesiology 96:742-752, 2002

O’Connor MF, Daves SM, Tung A, Cook RI, Thisted RA, Apfelbaum JL: BIS monitoring to prevent awareness during general anesthesia. Anesthesiology 94:520-522, 2001

Apfelbaum JL, O’Connor MF: Update on transfusion therapy. Semin Cardiothorac Vasc Anesth 4:236-243, 2000

Conley KM, Toledano AY, Apfelbaum JL, Zacny JP: Modulating effects of a cold water stimulus on opioid effects in volunteers. Psychopharmacology 131:313-320, 1997

Young CJ, Coalson D, Klock PA, Klafta JM, Goldsher G, Apfelbaum JL, Zacny JP: Analgesic and psychomotor effects of thiopental at subanesthetic concentrations in human volunteers. Acta Anaesthesiol Scand 41:903-910, 1997

Galinkin JL, Janiszewski D, Young CJ, Klafta JM, Klock PA, Coalson DW, Apfelbaum JL, Zacny JP: Subjective, psychomotor, cognitive, and analgesic effects of subanesthetic concentrations of sevoflurane and nitrous oxide. Anesthesiology 87:1082-1088, 1997

Cho AM, Coalson DW, Klock PA, Klafta JM, Marks S, Toledano AY, Apfelbaum JL, Zacny JP: The effects of alcohol history on the reinforcing, subjective and psychomotor effects of nitrous oxide in healthy volunteers. Drug Alcohol Depend 45:63-70, 1997

Zacny JP, Lichtor JL, Coalson DW, Alessi R, Goldsher G, Young CJ, Apfelbaum JL, Conley KM: Examining the subjective, psychomotor and reinforcing effects of nitrous oxide in healthy volunteers: a dose-response analysis. Behav Pharmacol 7:194-199, 1996

Zacny JP, Coalson DW, Klafta JM, Klock PA, Alessi R, Rupani G, Young CJ, Patil PG, Apfelbaum JL: Midazolam does not influence intravenous fentanyl-induced analgesia in healthy volunteers. Pharmacol Biochem Behav 55:275-280, 1996

Zacny JP, Klafta JM, Coalson DW, Marks S, Young CJ, Kock PA, Toledano AY, Jordan N, Apfelbaum JL: The reinforcing effects of brief exposures to nitrous oxide in healthy volunteers. Drug Alcohol Depend 42:197-200, 1996

Zacny JP, Yajnik S, Lichtor JL, Klafta JM, Young CJ, Thapar P, Rupani G, Coalson DW, Apfelbaum JL: The acute residual effects of subanesthetic concentrations of isoflurane/nitrous oxide combinations on cognitive and pyschomotor performance in healthy volunteers. Anesth Analg 82:153-157, 1996

Zacny JP, Lichtor JL, Klafta JM, Alessi R, Apfelbaum JL: The effects of transnasal butorphanol on mood and psychomotor functioning in healthy volunteers. Anesth Analg 82:931-935, 1996

Zacny JP, McKay MA, Toledano AY, Marks S, Young CJ, Klock PA, Apfelbaum JL: The effects of a cold-water immersion stressor on the reinforcing and subjective effects of fentanyl in healthy volunteers. Drug Alcohol Depend 42:133-142, 1996

Zacny JP, Coalson DW, Young CJ, Klafta JM, Lichtor JL, Rupani G, Thapar P, Apfelbaum JL: Propofol at conscious sedation doses produces mild analgesia to cold pressor-induced pain in healthy volunteers. J Clin Anesth 8:469-474, 1996

Yajnik S, Zacny JP, Young CJ, Lichtor JL, Rupani G, Klafta JM, Coalson DW, Apfelbaum JL: Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav 54:501-508, 1996

Apfelbaum JL, Lichtor JL, Lane BS, Coalson DW, Korttila KT: Awakening, clinical recovery, and psychomotor effects after desflurane and propofol anesthesia. Anesth Analg 83:721-725, 1996

Young CJ, Apfelbaum JL. Adult clinical experience with sevoflurane and pharmaco-economic aspects. Acta Anaesthesiol Belg 47:29-42, 1996

Zacny JP, Cho AM, Coalson DW, Rupani G, Young CJ, Klafta JM, Klock PA, Apfelbaum JL: Differential acute tolerance development to effects of nitrous oxide in humans. Neurosci Lett 209:73-76, 1996

Young CJ, Apfelbaum JL: Inhalational anesthetics: desflurane and sevoflurane. J Clin Anesth 7:564-577,

Apfelbaum JL: Mivacurium chloride administration by infusion. Acta Anaesthesiol Scand Suppl 106:55-57, 1995

Young CJ, Apfelbaum JL: Pharmacology of outpatient anesthesia in the year 2000. Acta Anaesthesiol Scand 39 (Suppl 105):75-83, 1995

Thapar P, Zacny JP, Choi M, Apfelbaum JL: Objective and subjective impairment from often-used sedative combinations in ambulatory surgery, using alcohol as a benchmark. Anesth Analg 80:1092-1098, 1995

Zacny JP, Yajnik S, Coalson D, Lichtor JL, Thapar P, Apfelbaum JL, Rupani G, Young C, Klafta J: Flumazenil may attenuate some subjective effects of nitrous oxide in humans: a preliminary report. Pharmacol Biochem Behav 51:815-819, 1995

Pirec V, Patterson TH, Thapar P Apfelbaum JL, Zacny JP: Effects of sub anesthetic concentrations of nitrous oxide on cold-pressor pain in humans. Pharmacol Biochem Behav 51:323-329, 1995

Pirec V, Coalson DW, Lichtor JL, Klafta J, Young C, Rupani G, Apfelbaum JL, Zacny JP: Cold water immersion modulates the reinforcing effects of nitrous oxide in healthy volunteers. Exp Clin Psychopharmacol 3:148-155, 1995

Thapar P, Zacny JP, Thompson W, Apfelbaum JL: Using alcohol as a metric to compare recovery profiles of often-used sedative agents in ambulatory surgery. Anesthesiology 82:53-59, 1995

Zacny JP, Coalson D, Young C, Klafta J, Rupani G, Thapar P, Choi M, Apfelbaum JL: A dose-response study of the effects of intravenous midazolam on cold pressor-induced pain. Anesth Analg 80:521-525, 1995

Thapar P, Korttila KT, Apfelbaum JL: Assessing recovery after day-case surgery. Curr Anaesth Crit Care 5:155-159, 1994

Zacny JP, Lichtor JL, Coalson DW, Flemming D, Apfelbaum JL, Foster V: Time course of effects of brief inhalations of nitrous oxide in normal volunteers. Addiction 89:831-839, 1994

Zacny JP, Lichtor JL, Thompson W, Apfelbaum JL: Propofol at a sub anesthetic dose may have abuse potential in healthy volunteers. Anesth Analg 77:544-552, 1993

White PF, Stanley TH, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Thisted RA, Walawander CA: Effects on recovery when isoflurane is used to supplement propofol-nitrous oxide anesthesia. Anesth Analg 77:S15-S20, 1993

Scuderi P, Wetchler B, Sung YF, Mingus M, DePen S, Clayton L, Leslie J, Talke P, Apfelbaum JL, Sharifi-Azad S, Williams MF: Treatment of postoperative nausea and vomiting after outpatient surgery with the 5HT3 antagonist ondansetron. Anesthesiology 78:15-20, 1993

Zacny JP, Lichtor, JL, Zaragoza JG, Apfelbaum JL: The effects of a 5-HT3 antagonist, ondansetron, on cigarette smoking, smoke exposure and mood in humans. Pharmacol Biochem Behav 44:387-391, 1993

Lichtor JL, Zacny JP, Coalson DW, Flemming DC, Uitvlugt A, Apfelbaum JL, Lane BS, Thisted RA: The interaction between alcohol and the residual effects of thiopental anesthesia. Anesthesiology 79:28-35, 1993

Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML: How do anesthesiologists select patients when introducing a new drug into practice? Anesth Analg 77:S30-S33, 1993

Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH: Phase IV study of propofol: Validation of the data set. Anesth Analg 77:S34-S43, 1993

McLeskey CH, Walawander CA, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, White PF, Apfelbaum JL, Grasela TH, Hug CC Jr: Adverse events in a multicenter phase IV study of propofol: Evaluation by anesthesiologists and postanesthesia care unit nurses. Anesth Analg 77:S3-S9, 1993

Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL, Grasela TH: Hemodynamic effects of propofol: Data from over 25,000 patients. Anesth Analg 77:S21-S29, 1993

Grasela TH, Watkins WD, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF, Apfelbaum JL: The role of pharmacoepidemiology research in postmarketing surveillance and anesthesia practice/critical care medicine. Anesth Analg 77:S44-S50, 1993

Apfelbaum JL, Grasela TH, Hug CC Jr, McLeskey CH, Nahrwold ML, Roizen MF, Stanley TH, Thisted RA, Walawander CA, White PF: The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: Characteristics associated with prolonged time to awakening. Anesth Analg 77:S10-S14, 1993

Zacny JP, Lichtor JL, Zaragoza JG, Coalson DW, Uitvlugt AM, Flemming DC, Binstock WB, Cutter T, Apfelbaum JL: Assessing the abuse potential of propofol bolus injections in healthy volunteers. Drug Alcohol Depend 32:45-57, 1993

Apfelbaum JL, Kallar SK, Wetchler B: Muscle relaxants for outpatient surgery: old and new. J Clin Anesth 4:2S-8S, 1992

Apfelbaum JL, Glosten B: Preoperative laboratory screening tests. Curr Surg 49:22-27, 1992

Roizen MF, Coalson D, Hayward RSA, Schmittner J, Thisted RA, Apfelbaum JL, Stocking CB, Cassel CK, Pompei P, Ford DE, Steinberg EP: Can patients use an automated questionnaire to define their current health status? Med Care 30:MS74-MS84, 1992

Apfelbaum JL: Mivacurium infusion. J Drug Dev S2:21-24, 1992

Lichtor JL, Zacny J, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C, Korttila K: Alcohol after sedation with I.V. midazolam-fentanyl: effects on psychomotor functioning. Br J Anaesth 67:579-584, 1992

Zacny JP, Lichtor JL, Coalson DW, Finn RS, Uitvlugt AM, Glosten B, Flemming DC, Apfelbaum JL: Subjective and psychomotor effects of subanesthetic doses of propofol in healthy volunteers. Anesthesiology 76:696-702, 1992

Korttila K, Nuotto EJ, Lichtor JL, Östman PL, Apfelbaum J, Rupani G: Clinical recovery and psychomotor function after brief anesthesia with propofol or thiopental. Anesthesiology 76:676-681, 1992

Lichtor JL, Zacny J, Korttila K, Apfelbaum JL, Lane BS, Rupani G, Thisted RA, Dohrn C: Alcohol after midazolam sedation: does it really matter? Anesth Analg 72:661-666, 1991

Apfelbaum JL: Organization and case selection. Acta Anaesth Scand 35(Suppl):I-33, 1991

Apfelbaum JL: Complications and quality assurance. Acta Anaesth Scand 35(Suppl): I-37, 1991

Korttila K, Östman P, Faure E, Apfelbaum JL, Prunskis J, Ekdawi M, Roizen MF: Randomized comparison of recovery after propofol-nitrous oxide versus thiopentone-isoflurane-nitrous oxide anaesthesia in patients undergoing ambulatory surgery. Acta Anaesthesiol Scand 34:400-403, 1990

Apfelbaum JL: Discussion highlights (part 2). Anesthesiol Rev 17 (Supl 2) 64-66, 1990

Apfelbaum JL: Discussion highlights (part 1). Anesthesiol Rev 17 (Suppl 2):28-31, 1990

Apfelbaum JL: Preoperation evaluation, laboratory screening, and selection of adult surgical outpatients in the 1990s. Anesthesiol Rev 17 (Suppl 2):4-12, 1990 Apfelbaum JL: Ambulatory surgery: A historical perspective. Anesthesiol Rev 17 (Suppl 2):2-3, 1990

Korttila K, Östman PL, Faure E, Apfelbaum JL, Ekdawi M, Roizen MF: Randomized comparison of outcome after propofol-nitrous oxide or enflurane-nitrous oxide anaesthesia in operations of long duration. Can J Anaesth 36:651-657, 1989

Zahl K, Apfelbaum JL: Muscle pain occurs after outpatient laparoscopy despite the substitution of vecuronium for succinylcholine. Anesthesiology 70:408-411, 1989

Marais ML, Maher MW, Wetchler BV, Korttila K, Apfelbaum JL: Reduced demands on recovery room resources with propofol (Diprivan) compared to thiopental-isoflurane. Anesthesiol Rev 16:29-40, 1989

Apfelbaum JL, Schreider BD: Organizational aspects of day-case surgery. Curr Opin Anaesth 1:48-53, 1988

Conahan TJ, Williams GD, Apfelbaum JL, Lecky JH: Airway heating reduces recovery time (cost) in outpatients. Anesthesiology 61:128-130, 1987

Leighton BL, Cheek TG, Gross JB, Apfelbaum JL, Shantz BB, Gutsche BB, Rosenberg H: Succinylcholine pharmacodynamics in peripartum patients. Anesthesiology 64:202-206, 1986

Moss J, Roizen MF, Norbody EJ, Thisted R, Apfelbaum JL, Schreider BD, McDermott DJ: Decreased incidence and mortality of anaphylaxis to chymopapain. Anesth Analg 64:1197-1201, 1985

Apfelbaum JL, Shaw LM, Gross JB, Caldwell CB, Spaulding BC: Modifications of lidocaine protein binding with CO2. Can Anaesth Soc J 32:468-471, 1985

Choi SD, Spaulding BC, Gross JB, Apfelbaum JL: Comparison of the ventilatory effects of etomidate and methohexital. Anesthesiology 62:442-447, 1985

Spaulding BC, Choi SD, Gross JB, Apfelbaum JL, Broderson H: The effect of physostigmine on diazepam-induced ventilatory depression: A double-blind study. Anesthesiology 61:551-554, 1984

Coodley EL, Miller H, Frocco G, Goldzer R, LaBove N, LeSal J, Neimark S, Victor M, Whittington R, Apfelbaum JL: Therapeutic conference: Problem: Fever, nausea, back pain. Emerg Med 16:57-64, 1984

Gross JB, Caldwell CB, Shaw LM, Apfelbaum JL: Effect of lidocaine infusion on the ventilatory response to hypoxia. Anesthesiology 61:662-666, 1984